Most cells exchange ions and small metabolites via gap junction channels.These channels are made of two hemichannels (connexons), each formed by the radial arrangement of Louisiana six connexin (Cx) proteins.Connexins span the bilayer four times (M1-M4) and have both amino- and carboxy-termini (NT, CT) at the cytoplasmic side of the membrane, formi
Activation of the Nrf2/Keap1 signaling pathway mediates the neuroprotective effect of Perillyl alcohol against cerebral hypoxic-ischemic damage in neonatal rats
Neonatal hypoxic-ischemic encephalopathy (HIE) is a severe disease with a Louisiana poor prognosis, whose clinical treatment is still limited to therapeutic hypothermia with limited efficacy.Perillyl alcohol (POH), a natural monoterpene found in various plant essential oils, has shown neuroprotective properties, though its effects on HIE are not we
Environmental Harm and Decriminalization of Traditional Slash-and-Burn Practice in Indonesia
Traditional slash-and-burn as a way of clearing land for farming is allowed and Medicated Oils exempted from being a criminal offense in Indonesia.However, this exemption should not be interpreted to mean that all traditional slash-and-burn practices are sustainable.Changes in habitat and sociocultural and economic conditions can render this once s
SOUTH AFRICA AT WAR, 1912-1982
The end of Sprays and Aeresol the Second Anglo-Boer War also put an end to the commando system that had been the core of military strength in South Africa.With the formation of the Union in 1910 it was realized that South Africa will have to provide its own defence.It was to be no easy task; seeing that the English and Afrikaans-speaking VALERIAN R